AUTHOR=Coca Armando , Burballa Carla , Centellas-Pérez Francisco Javier , Pérez-Sáez María José , Bustamante-Munguira Elena , Ortega Agustín , Dueñas Carlos , Arenas María Dolores , Pérez-Martínez Juan , Ruiz Guadalupe , Crespo Marta , Llamas Francisco , Bustamante-Munguira Juan , Pascual Julio
TITLE=Outcomes of COVID-19 Among Hospitalized Patients With Non-dialysis CKD
JOURNAL=Frontiers in Medicine
VOLUME=7
YEAR=2020
URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2020.615312
DOI=10.3389/fmed.2020.615312
ISSN=2296-858X
ABSTRACT=Background: Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome-Corona Virus 2 has generated significant impact on global health worldwide. COVID-19 can cause pneumonia and organ injury. Chronic kidney disease (CKD) has been associated with increased mortality in previous epidemics, but there is a paucity of data regarding actual risks for non-dialysis CKD patients with COVID-19.
Methods: Multicenter, observational cohort study including 136 non-dialysis CKD patients and 136 age- and sex-matched controls that required hospitalization due to COVID-19. Patients with end-stage renal disease, a kidney transplant or without registered baseline glomerular filtration rate prior to COVID-19 infection were excluded. CKD and acute kidney injury (AKI) were defined according to KDIGO criteria.
Results: CKD patients had higher white blood cell count and D-dimer and lower lymphocyte percentage. No differences were found regarding symptoms on admission. CKD was associated with higher rate of AKI (61 vs. 24.3%) and mortality (40.4 vs. 24.3%). Patients with AKI had the highest hazard for death (AKI/non-CKD HR:7.04, 95% CI:2.87–17.29; AKI/CKD HR:5.25, 95% CI: 2.29–12.02), followed by CKD subjects without AKI (HR:3.39, 95% CI:1.36–8.46). CKD status did not condition ICU admission or length of in-hospital stay.
Conclusions: CKD patients that require hospitalization due to COVID-19 are exposed to higher risk of death and AKI.