AUTHOR=Merkulova Alona A. , Mitchell Steven C. , Merkulov Sergei , Wolberg Alisa S. , Neerman-Arbez Marguerite , Schmaier Alvin H. 

TITLE=Case Report: Unmasked Inherited Dysfibrinogenemia After Everolimus Therapy

JOURNAL=Frontiers in Medicine

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2020.591546

DOI=10.3389/fmed.2020.591546

ISSN=2296-858X

ABSTRACT=<p>A previously hemostatically asymptomatic patient with common variable hypogammaglobulinemia was given everolimus to prevent growth of her liver. Within several months, the patient developed a severe bleeding disorder. The bleeding was due to fibrin polymerization defect that upon sequencing was shown to be dysfibrinogenemia Krakow III. Elimination of the mTor inhibitor ameliorated the clinical bleeding state.</p>