AUTHOR=Wu Xinyu , Wu Jialing , Li Xiaomin , Wei Qiujing , Lv Qing , Zhang Pingping , Zheng Xuqi , Chen Zena , Cao Shuangyan , Tu Liudan , Gu Jieruo 

TITLE=The Clinical Characteristics of Other HLA-B Types in Chinese Ankylosing Spondylitis Patients

JOURNAL=Frontiers in Medicine

VOLUME=7

YEAR=2021

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2020.568790

DOI=10.3389/fmed.2020.568790

ISSN=2296-858X

ABSTRACT=<p>HLA-B27 has an established relationship with the development of ankylosing spondylitis (AS). After reviewing the HLA-B genotype from 407 Chinese subjects (318 patients and 89 sex-matched controls), we found that 252 patients and 32 controls were HLA-B27(+) and that HLA-B<sup>*</sup>27:04 was the dominant HLA-B27 subtype (<italic>N</italic> = 224). In all participants, HLA<sup>*</sup>27:04 homozygous were only detected in two patients. In the HLA-B27(+) group, HLA-B40 was observed in 51 cases and one control (<italic>p</italic> &lt; 0.05, OR = 7.87, 95% CI 1.05–59.0); of these, the most genotype was HLA-B<sup>*</sup>27:04/B<sup>*</sup>40:01(<italic>N</italic> = 38). Two hundred thirty-nine patients' clinical information was recorded. Cases with HLA-B27/B46 had more peripheral joint involvement (OR = 3.95, 95% CI 1.77–8.79) in HLA-B27(+) AS. HLA-B<sup>*</sup>15:02 may be a significant risk element to peripheral joint involvement (<italic>p</italic> &lt; 0.05) in HLA-B27(−) patients. Therefore, we believe HLA-B<sup>*</sup>40:01, HLA-B<sup>*</sup>46:01, and HLA-B<sup>*</sup>15:02 can be the test indicators for AS diagnostic value.</p>