AUTHOR=Li Man , Cheng Biao , Zeng Wen , Chen Sichao , Tu Mengqi , Wu Meng , Tong Wei , Wang Shipei , Huang Yihui , Long Wei , Zhou Wei , Chen Danyang , Zhou Lin , Wang Min , Xu Haibo , Deng Aiping , Liu Zeming , Guo Liang 

TITLE=Analysis of the Risk Factors for Mortality in Adult COVID-19 Patients in Wuhan: A Multicenter Study

JOURNAL=Frontiers in Medicine

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2020.00545

DOI=10.3389/fmed.2020.00545

ISSN=2296-858X

ABSTRACT=<p><bold>Objectives:</bold> An outbreak of coronavirus disease (COVID-19) in 2019 in Wuhan, China, has spread quickly worldwide. However, the risk factors associated with COVID-19-related mortality remain controversial.</p><p><bold>Methods:</bold> A total of 245 adult patients with laboratory-confirmed COVID-19 from two centers were analyzed. Chi-square, Fisher's exact, and the Mann-Whitney <italic>U</italic>-tests were used to compare the clinical characteristics between the survivors and non-survivors. To explore the risk factors associated with in-hospital death, univariable and multivariable cox regression analyses were used.</p><p><bold>Results:</bold> Of the 245 patients included in this study, 23 (9.4%) died in the hospital. The multivariate regression analysis showed increased odds of in-hospital deaths associated with age, D-dimer levels &gt;1,000 ng/L, platelet count &lt;125, and higher serum creatinine levels.</p><p><bold>Conclusions:</bold> We identified risk factors that show significant association with mortality in adult COVID-19 patients, and our findings provide valuable references for clinicians to identify high-risk patients with COVID-19 at an early stage.</p>