AUTHOR=Duan Ting , Jiang Hanyu , Xia Chunchao , Chen Jie , Cao Likunn , Ye Zheng , Wei Yi , Song Bin , Lee Jeong Min 

TITLE=Assessing Liver Function in Liver Tumors Patients: The Performance of T1 Mapping and Residual Liver Volume on Gd-EOBDTPA-Enhanced MRI

JOURNAL=Frontiers in Medicine

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2020.00215

DOI=10.3389/fmed.2020.00215

ISSN=2296-858X

ABSTRACT=<p><bold>Purpose:</bold> To assess the performance of T1 mapping and residual liver volume (RLV) on Gd-EOBDTPA-enhanced MRI in pretreatment estimation of liver function in patients with liver tumors. Indocyanine green retention rate at 15 min (ICG R-15) was used as a reference standard.</p><p><bold>Methods:</bold> Ethical approval from the institutional review board and informed consent were obtained for this prospective study. We enrolled 155 patients with liver tumors who underwent pretreatment Gd-EOB-DTPA-enhanced MRI. T1 relaxation time before (T1-pre), 20 min after (T1-post) Gd-EOB-DTPA injection and RLV were measured. The absolute reduction (ΔT1) and reduction rate (ΔT1%) of T1 relaxation time, volume-assisted ΔT1 (ΔT1<sup>*</sup>RLV) and volume-assisted ΔT1% (ΔT1%<sup>*</sup>RLV) were calculated accordingly. The correlation of MR parameters with ICG R-15 was determined using Spearman's rank correlation analysis. Patients were classified into the normal liver function (NLF) group if their ICG R-15 levels were &lt;10% or otherwise into the abnormal liver function (ALF) group. Receiver operating characteristic (ROC) analysis was conducted to evaluate the performances of the MR parameters in predicting ALF.</p><p><bold>Results:</bold> T1-post (<italic>r</italic> = 0.472, <italic>P</italic> &lt; 0.001), ΔT1 (<italic>r</italic> = −0.355, <italic>P</italic> = 0.011), ΔT1% (<italic>r</italic> = −0.482, <italic>P</italic> &lt; 0.001), RLV (<italic>r</italic> = −0.336, <italic>P</italic> &lt; 0.001), volume-assisted ΔT1 (<italic>r</italic> = −0.458, <italic>P</italic> &lt; 0.001) and volume-assisted ΔT1% (<italic>r</italic> = −0.522, <italic>P</italic> &lt; 0.001) showed weak to moderate correlation with ICG R-15. The area under the ROC curves (AUROC) of volume-assisted ΔT1 in predicting ALF was 0.777, which was significantly higher than the other parameters (<italic>P</italic> &lt; 0.05 for all).</p><p><bold>Conclusions:</bold> Combined T1 mapping and RLV on Gd-EOB-DTPA-enhanced MRI can help assess liver function with good diagnostic accuracy in patients with liver tumors before treatment.</p>