AUTHOR=Deng Xiaorong , Tian Huakai , Yang Rong , Han Yiwen , Wei Kehong , Zheng Cihua , Liu Zhaoxia , Chen Tingtao 

TITLE=Oral Probiotics Alleviate Intestinal Dysbacteriosis for People Receiving Bowel Preparation

JOURNAL=Frontiers in Medicine

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2020.00073

DOI=10.3389/fmed.2020.00073

ISSN=2296-858X

ABSTRACT=<p><bold>Background:</bold> Bowel preparation is necessary for successful colonoscopy, while it can seriously affect intestinal microbial composition and damage the intestinal mucosal barriers in humans.</p><p><bold>Methods:</bold> To figure out whether probiotics can sustain intestinal homeostasis and guard people's health, the probiotic drug of <italic>Bifidobacterium</italic> Tetragenous viable Bacteria Tablets (P group, <italic>n</italic> = 16) or placebo (C group, <italic>n</italic> = 16) was used for volunteers receiving bowel preparation, and high-throughput sequencing method was applied to monitor their intestinal microbial changes.</p><p><bold>Results:</bold> The present results suggested that bowel preparation obviously reduced the intestinal microbial diversity, while taking probiotics significantly restored it to normal level. In addition, probiotics sharply reduced the abundance of pathogenic <italic>Proteobacteria</italic>, and obviously lowered the ratio of <italic>Firmicutes/Bacteroidetes</italic> compared with control group at phylum level (<italic>P</italic> &lt; 0.05). And probiotics markedly decreased the abundance of pathogenic <italic>Acinetobacter</italic> and <italic>Streptococcus</italic>, while greatly enriched the relative abundance of beneficial bacteria <italic>Bacteroides, Roseburia, Faecalibacterium</italic>, and <italic>Parabacteroides</italic> at genus level (<italic>P</italic> &lt; 0.05).</p><p><bold>Conclusion:</bold> Probiotic drugs, e.g., <italic>Bifidobacterium</italic> Tetragenous viable Bacteria Tablets, can be used to restore intestinal dysbacteriosis caused by bowel preparation, and reduce side effects during colonoscopy.</p>