AUTHOR=Shen Gang , Wu Linlin , Zhao Jie , Wei Bin , Zhou Xianjun , Wang Feifei , Liu Jie , Dong Qian 

TITLE=Clinical and Pathological Study of Tumor Border Invasion—Is Narrow Resection Margin Acceptable in Hepatoblastoma Surgery?

JOURNAL=Frontiers in Medicine

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2020.00059

DOI=10.3389/fmed.2020.00059

ISSN=2296-858X

ABSTRACT=<p><bold>Aim:</bold> We aim to study clinically and pathologically whether narrow resection margin (&lt;1 cm) is acceptable in hepatoblastoma surgery.</p><p><bold>Methods:</bold> A total of 42 patients who underwent surgery for hepatoblastoma were selected, and these patients were divided into two groups according to whether or not they underwent preoperative chemotherapy (CHT). The general characteristics of the patients were summarized, the resection margin distance was recorded, and the event-free survival rates were followed up. Pathologically, H&amp;E staining and immunochemical staining were used to study the invasion distance outside the tumor capsule in the tumor border.</p><p><bold>Results:</bold> Clinically, the event-free survival rates were not significantly different between the patients with wide resection margin (&gt;1 cm) and narrow resection margin (&lt;1 cm) of the two groups. Pathologically, the tumor of all 42 patients had capsules surrounding the tumor. Of the patients in Group 1 (without preoperative CHT), 9% (2/22) had micrometastatic cancer nests outside the capsule, and the farthest distance from the cancer nests to the capsule was 4.6 mm. Of the patients in Group 2 (with preoperative CHT), 75% (15/20) showed residual cancer nests in the paratumor liver tissue, and the farthest distance was 9.6 mm; three and two cases, respectively, showed extracapsular intravascular microtumorous thrombi.</p><p><bold>Conclusion:</bold> Clinically and pathologically, narrow resection margin is acceptable in hepatoblastoma surgery.</p>