AUTHOR=Lan Qin , Wu Hong , Zhou Xiaohui , Zheng Liang , Lin Fang , Meng Qingshu , Xi Xiaoling , Yue Aixue , Buys Nicholas , Sun Jing , Liu Zhongmin , Li Jue , Fan Huimin 

TITLE=Predictive Value of Uric Acid Regarding Cardiometabolic Disease in a Community-Dwelling Older Population in Shanghai: A Cohort Study

JOURNAL=Frontiers in Medicine

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2020.00024

DOI=10.3389/fmed.2020.00024

ISSN=2296-858X

ABSTRACT=<p><bold>Aim:</bold> This study aimed to test the predictive power of serum uric acid (UA) levels on new-onset cardiometabolic risk in the Chinese population.</p><p><bold>Methods:</bold> Older people who visited a community health center for a yearly health check (<italic>N</italic> = 5,000; men: 47%, women: 53%) were enrolled. Participants were followed for 4 years from baseline (median: 48 months), with the endpoints being development of heart failure, atrial fibrillation, diabetes, hypertension, metabolic syndrome, or kidney disease.</p><p><bold>Results:</bold> During follow-up, 342 men (7.4%) and 360 women (8.6%) developed hypertension; 98 men (2.48%) and 135 women (3.06%) developed diabetes; and 175 men (5.04%) and 214 women (4.51%) developed metabolic syndrome. Incident diabetes, hypertension, and metabolic syndrome increased with increased UA levels at baseline (<italic>P</italic> &lt; 0.001). A multivariate Cox proportional hazards analysis revealed a significant, independent association between the baseline UA level and the onset and future hypertension and/or diabetes in both men and women. However, UA is associated with the development of metabolic syndrome in men, but not in women.</p><p><bold>Conclusion:</bold> UA is an independent predictor of new-onset diabetes and hypertension in both women and men and a predictor of new-onset metabolic syndrome only in men.</p>