AUTHOR=Hsiao Chih-Yen , Chen Tsung-Hsien , Lee Yi-Chien , Hsiao Meng-Chang , Hung Peir-Haur , Chen Yih-Yuan , Wang Ming-Cheng 

TITLE=Urolithiasis Is a Risk Factor for Uroseptic Shock and Acute Kidney Injury in Patients With Urinary Tract Infection

JOURNAL=Frontiers in Medicine

VOLUME=6

YEAR=2019

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2019.00288

DOI=10.3389/fmed.2019.00288

ISSN=2296-858X

ABSTRACT=<p>Urinary tract infection (UTI) is a common complication in patients with urolithiasis. This study aimed to compare clinical manifestations and treatment outcomes among UTI patients with or without urolithiasis. It also focused on identifying relationships among urolithiasis, uroseptic shock, and acute kidney injury (AKI). This retrospective study enrolled hospitalized UTI patients who underwent imaging in an acute care setting from January 2006 to March 2015. Of 662 participants enrolled, 113 (17.1%) had urolithiasis, 107 (16.2%) developed uroseptic shock, and 184 (27.8%) developed AKI. A multivariate logistic regression analysis showed that in UTI patients, urolithiasis is associated with an increased risk of uroseptic shock (OR 1.80, 95% CI: 1.08–3.02, <italic>P</italic> = 0.025), AKI (OR 1.95, 95% CI: 1.22–3.12, <italic>P</italic> = 0.005), and bacteremia (OR 1.68, 95% CI: 1.08–2.64, <italic>P</italic> = 0.022). Urolithiasis is common in UTI patients and is associated with an increased risk of uroseptic shock and AKI.</p>