AUTHOR=Boisson-Vidal Catherine , Benslimane-Ahmim Zahia , Lokajczyk Anna , Heymann Dominique , Smadja David M. TITLE=Osteoprotegerin Induces CD34+ Differentiation in Endothelial Progenitor Cells JOURNAL=Frontiers in Medicine VOLUME=5 YEAR=2018 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00331 DOI=10.3389/fmed.2018.00331 ISSN=2296-858X ABSTRACT=
Endothelial progenitor cells (EPCs) are the main hypothetical cells that could give rise to vessels and in particular one subtype isolated from peripheral or cord bloods: endothelial colony forming cells (ECFCs). These ECFCs are clonogenic precursors committed to endothelial lineage and have robust vasculogenic properties. However, their low number and poor expansion properties when isolated from human adult bloods, currently limit their use as an autologous cell therapy product. We previously reported that osteoprotegerin (OPG), a well-characterized regulator of bone metabolism, contributes to ischemic tissue revascularization, tumor growth