AUTHOR=Vivaldo Jessica Fernandes , de Amorim Jaqueline Cristina , Julio Paulo Rogério , de Oliveira Rodrigo Joel , Appenzeller Simone 

TITLE=Definition of NPSLE: Does the ACR Nomenclature Still Hold?

JOURNAL=Frontiers in Medicine

VOLUME=5

YEAR=2018

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00138

DOI=10.3389/fmed.2018.00138

ISSN=2296-858X

ABSTRACT=<p>Systemic lupus erythematosus (SLE) patients have frequently neuropsychiatric manifestations. From the first description of coma in 1875, a variety of manifestations has been described to occur in SLE. However, the lack of standardization reduced the comparability of published studies. In 1999, the American College of Rheumatology published guidelines to define neuropsychiatric nomenclature in SLE. This was the first step toward uniform diagnostic criteria. Several studies have been published since then applying the ACR criteria and frequencies of different manifestations can now be compared between cohorts. Although these criteria are diagnostic, therapeutic approach to different manifestations varies according to nature and severity of the manifestations. Herby, we will review the different definition for NPSLE published, and determine advantages and limitation.</p>