AUTHOR=Zajac Paul , Schultz-Thater Elke , Tornillo Luigi , Sadowski Charlotte , Trella Emanuele , Mengus Chantal , Iezzi Giandomenica , Spagnoli Giulio C. 

TITLE=MAGE-A Antigens and Cancer Immunotherapy

JOURNAL=Frontiers in Medicine

VOLUME=4

YEAR=2017

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2017.00018

DOI=10.3389/fmed.2017.00018

ISSN=2296-858X

ABSTRACT=<p>MAGE-A antigens are expressed in a variety of cancers of diverse histological origin and germinal cells. Due to their relatively high tumor specificity, they represent attractive targets for active specific and adoptive cancer immunotherapies. Here, we (i) review past and ongoing clinical studies targeting these antigens, (ii) analyze advantages and disadvantages of different therapeutic approaches, and (iii) discuss possible improvements in MAGE-A-specific immunotherapies.</p>