AUTHOR=Fischler Rebecca , Meert Anne-Pascale , Sculier Jean-Paul , Berghmans Thierry 

TITLE=Continuous Renal Replacement Therapy for Acute Renal Failure in Patients with Cancer: A Well-Tolerated Adjunct Treatment

JOURNAL=Frontiers in Medicine

VOLUME=3

YEAR=2016

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2016.00033

DOI=10.3389/fmed.2016.00033

ISSN=2296-858X

ABSTRACT=<sec id="ST1"><title>Introduction</title><p>Acute renal failure (ARF) has a poor prognosis in patients with cancer requiring intensive care unit (ICU) admission. Our aim is finding prognostic factors for hospital mortality in patients with cancer with ARF requiring renal replacement therapy (RRT).</p></sec><sec id="ST2"><title>Methods</title><p>In this retrospective study, all patients with cancer with ARF treated with continuous venovenous filtration (CVVHDF) in the ICU of the Institut Jules Bordet, between January 1, 2003 and December 31, 2012, were included.</p></sec><sec id="ST3"><title>Results</title><p>One hundred and three patients are assessed: men/women 69/34, median age 62 years, solid/hematologic tumors 68/35, median SAPS II 56. Mortality rate was 63%. Seven patients required chronic renal dialysis. After multivariate analysis, two variables were statistically associated with hospital mortality: more than one organ failure (including kidney) (OR 5.918; 95% CI 2.184–16.038; <italic>p</italic> &lt; 0.001) and low albumin level (OR 3.341; 95% CI 1.229–9.077; <italic>p</italic> = 0.02). Only minor complications related to CVVHDF have been documented.</p></sec><sec id="ST4"><title>Conclusion</title><p>Despite the poor prognosis associated with ARF, CVVHDF is an effective and tolerable renal replacement technique in patients with cancer admitted to the ICU. Multiple organ failure and hypoalbuminemia, two independent prognostic factors for hospital mortality have to be considered when deciding for introducing RRT.</p></sec>