AUTHOR=Chaturvedi Shubhra , Mishra Anil K. TITLE=Small Molecule Radiopharmaceuticals – A Review of Current Approaches JOURNAL=Frontiers in Medicine VOLUME=3 YEAR=2016 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2016.00005 DOI=10.3389/fmed.2016.00005 ISSN=2296-858X ABSTRACT=

Radiopharmaceuticals are an integral component of nuclear medicine and are widely applied in diagnostics and therapy. Though widely applied, the development of an “ideal” radiopharmaceutical can be challenging. Issues such as specificity, selectivity, sensitivity, and feasible chemistry challenge the design and synthesis of radiopharmaceuticals. Over time, strategies to address the issues have evolved by making use of new technological advances in the fields of biology and chemistry. This review presents the application of few advances in design and synthesis of radiopharmaceuticals. The topics covered are bivalent ligand approach and lipidization as part of design modifications for enhanced selectivity and sensitivity and novel synthetic strategies for optimized chemistry and radiolabeling of radiopharmaceuticals.