AUTHOR=Colombié Mathilde , Gouard Sébastien , Frindel Mathieu , Vidal Aurélien , Chérel Michel , Kraeber-Bodéré Françoise , Rousseau Caroline , Bourgeois Mickaël TITLE=Focus on the Controversial Aspects of 64Cu-ATSM in Tumoral Hypoxia Mapping by PET Imaging JOURNAL=Frontiers in Medicine VOLUME=2 YEAR=2015 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2015.00058 DOI=10.3389/fmed.2015.00058 ISSN=2296-858X ABSTRACT=
Mapping tumor hypoxia is a great challenge in positron emission tomography (PET) imaging as the precise functional information of the biological processes is needed for many effective therapeutic strategies. Tumor hypoxia has been widely reported as a poor prognostic indicator and is often associated with tumor aggressiveness, chemo- and radio-resistance. An accurate diagnosis of hypoxia is a challenge and is crucial for providing accurate treatment for patients’ survival benefits. This challenge has led to the emergence of new and novel PET tracers for the functional and metabolic characterization of tumor hypoxia non-invasively. Among these tracers, copper semicarbazone compound [64Cu]-diacetyl-bis(