AUTHOR=Ghidini Michele , Braconi Chiara 

TITLE=Non-Coding RNAs in Primary Liver Cancer

JOURNAL=Frontiers in Medicine

VOLUME=2

YEAR=2015

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2015.00036

DOI=10.3389/fmed.2015.00036

ISSN=2296-858X

ABSTRACT=<p>Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with poor prognosis and limited therapeutic options. Over the past few years, many studies have evaluated the role of non-coding RNAs (ncRNAs) in hepatocarcinogenesis and tumor progression. ncRNAs were shown to have diagnostic, prognostic, and therapeutic potential in HCC. In this manuscript, we review the latest major discoveries concerning microRNAs and long ncRNAs in HCC pathogenesis, and discuss the potentials and the limitations for their use in clinical practice.</p>