AUTHOR=Chaturvedi Vivek K. , Sharma Bhaskar , Tripathi Abhay Dev , Yadav Dawesh P. , Singh Kshitij RB , Singh Jay , Singh Ravindra Pratap TITLE=Biosynthesized nanoparticles: a novel approach for cancer therapeutics JOURNAL=Frontiers in Medical Technology VOLUME=5 YEAR=2023 URL=https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2023.1236107 DOI=10.3389/fmedt.2023.1236107 ISSN=2673-3129 ABSTRACT=

Nanotechnology has become one of the most rapid, innovative, and adaptable sciences in modern science and cancer therapy. Traditional chemotherapy has limits owing to its non-specific nature and adverse side effects on healthy cells, and it remains a serious worldwide health issue. Because of their capacity to specifically target cancer cells and deliver therapeutic chemicals directly to them, nanoparticles have emerged as a viable strategy for cancer therapies. Nanomaterials disclose novel properties based on size, distribution, and shape. Biosynthesized or biogenic nanoparticles are a novel technique with anti-cancer capabilities, such as triggering apoptosis in cancer cells and slowing tumour growth. They may be configured to deliver medications or other therapies to specific cancer cells or tumour markers. Despite their potential, biosynthesized nanoparticles confront development obstacles such as a lack of standardisation in their synthesis and characterization, the possibility of toxicity, and their efficiency against various forms of cancer. The effectiveness and safety of biosynthesized nanoparticles must be further investigated, as well as the types of cancer they are most successful against. This review discusses the promise of biosynthesized nanoparticles as a novel approach for cancer therapeutics, as well as their mode of action and present barriers to their development.