AUTHOR=Rossi Martina , Blasi Paolo 

TITLE=Multicellular Tumor Spheroids in Nanomedicine Research: A Perspective

JOURNAL=Frontiers in Medical Technology

VOLUME=4

YEAR=2022

URL=https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2022.909943

DOI=10.3389/fmedt.2022.909943

ISSN=2673-3129

ABSTRACT=<p>Multicellular tumor spheroids are largely exploited in cancer research since they are more predictive than bi-dimensional cell cultures. Nanomedicine would benefit from the integration of this three-dimensional <italic>in vitro</italic> model in screening protocols. In this brief work, we discuss some of the issues that cancer nanomedicine will need to consider in the switch from bi-dimensional to three-dimensional multicellular tumor spheroid models.</p>