AUTHOR=Silva Celio Lopes , Malardo Thiago , Tahyra Aline Seiko Carvalho 

TITLE=Immunotherapeutic Activities of a DNA Plasmid Carrying the Mycobacterial hsp65 Gene (DNAhsp65)

JOURNAL=Frontiers in Medical Technology

VOLUME=2

YEAR=2020

URL=https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2020.603690

DOI=10.3389/fmedt.2020.603690

ISSN=2673-3129

ABSTRACT=<p>DNA vaccines have become relevant subject matter, and efforts for their development have been increasing due to their potential as technology platforms applicable for prophylactic and therapeutic approaches for infectious diseases and for cancer treatment, allergies, and autoimmune diseases. This review aimed to summarize current knowledge about the plasmid DNA vaccine carrying the mycobacterial hsp65 gene (DNAhsp65), which demonstrates immunomodulatory and immunoregulatory properties of both the innate and adaptive immune systems. The possible mechanisms associated with the modulation and regulatory role of DNAhsp65 in the control of various conditions is also discussed.</p>