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ORIGINAL RESEARCH article

Front. Med. Eng.
Sec. Advanced Technologies for Medicine
Volume 2 - 2024 | doi: 10.3389/fmede.2024.1484232

Gluing Osteochondral Fragments: Development of a Novel Strategy for Dual Adhesive Application in a Preclinical Model

Provisionally accepted
Alicja J. Bojan Alicja J. Bojan 1,2*Peyman Karami Peyman Karami 3Philip Procter Philip Procter 4Dominique P. Pioletti Dominique P. Pioletti 3
  • 1 Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  • 2 Department of Orthopedics, Sahlgrenska University Hospital, Gothenburg, Sweden
  • 3 Laboratory of Biomechanical Orthopedics, Swiss Federal Institutes of Technology, Lausanne, Vaud, Switzerland
  • 4 Department of Engineering Sciences, Uppsala University, Uppsala, Uppsala, Sweden

The final, formatted version of the article will be published soon.

    This study proposes a novel dual adhesive approach for fixing osteochondral fractures, aiming to address the limitations of current fixation methods by incorporating both a bone adhesive (phosphoserine modified calcium phosphate cement PM-CPC) and a cartilage adhesive (methacrylated phosphoserine-containing gelatin MePGa hydrogel). The feasibility and efficacy of this approach were investigated using an ex vivo bovine knee model. Results indicate successful gluing of osteochondral cylinders with both adhesives, with no significant difference in adhesion strength between the groups (adhesion strength mean of 1105.8 kPa, SD 602.4 kPa, and mean of 1186.1 kPa, SD 850.9 kPa for groups 1 and 2 respectively). Importantly, the inclusion of the hydrogel component in the dual adhesive system aims to enhance cartilage repair potential, complementing the mechanical support provided by the bone adhesive. Each adhesive offers distinctive benefits: PM-CPC for mechanical support and bone repair, and MePGa hydrogel for cartilage repair. The study demonstrates the potential of the dual adhesive strategy for osteochondral repair, though further refinement and in vivo validation are needed.

    Keywords: Articular fracture, Cartilage, Subchondral Bone, Hydrogel, Calcium-phosphate cement

    Received: 21 Aug 2024; Accepted: 29 Oct 2024.

    Copyright: © 2024 Bojan, Karami, Procter and Pioletti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Alicja J. Bojan, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 405 30, Sweden

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.