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REVIEW article
Front. Mater.
Sec. Biomaterials and Bio-Inspired Materials
Volume 12 - 2025 | doi: 10.3389/fmats.2025.1534127
Knowledge map in biomaterials and related immune response: A scientometric analysis
Provisionally accepted- Stomatological Hospital of Chongqing Medical University, Chongqing, China
Background: Biomaterials have seen extensive use in biomedicine in the past decade.However, being foreign substances when implanted in the human body, they inevitably trigger immune responses. This study aimed to summarize existing articles on biomaterials and immune responses and explore their latest trends.We used the Web of Science Core Collection database (WoSCC) to access literature related to biomaterials and immune response. This comprehensive review of the knowledge domain allowed us to identify potential future research directions.In this study, we analyzed 5993 articles on biomaterials and immune response published between 1990 and 2022. Badylak, SF, stood out with the highest number of publications, the highest h-index, and the most average citations. The Journal of Biomaterials secured the top position as the most productive journal with the highest citation count. The emerging research hotspots are centered in regeneration medicine around keywords such as "biocompatibility," "wound healing," "osteogenesis," "angiogenesis," and "bone regeneration."The present study summarizes the global trends in biomaterials and immune response. Future efforts should concentrate on advancing the application of biomaterials in the medical field, conducting in-depth mechanistic studies, exploring the intricacies of immune responses, and ensuring the biosafety of biomaterials.
Keywords: Biomaterials, immune response, Bibliometric, Trends, Emerging topics
Received: 25 Nov 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Yu, Xu, Wang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chongqing Yu, Stomatological Hospital of Chongqing Medical University, Chongqing, China
Tao Wang, Stomatological Hospital of Chongqing Medical University, Chongqing, China
Jie Xu, Stomatological Hospital of Chongqing Medical University, Chongqing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.