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ORIGINAL RESEARCH article

Front. Mater.
Sec. Biomaterials and Bio-Inspired Materials
Volume 11 - 2024 | doi: 10.3389/fmats.2024.1514559
This article is part of the Research Topic Bioactive Coatings: Advancing Bone Implant Performance and Longevity View all 3 articles

"Optimizing Bone-Metal Implant Interfaces: The Role of Bio-Ceramic Coatings in Improving Stability and Tissue Metabolism"

Provisionally accepted
Geetha Balasubramani Geetha Balasubramani 1,2*Premkumar J Premkumar J 2Paul Pradeep Paul Pradeep 1
  • 1 Department of Electronics, Information and Bioengineering, Polytechnic University of Milan, Milan, Italy
  • 2 Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India

The final, formatted version of the article will be published soon.

    Bone replacement is often necessary for patients experiencing pain or swelling in the knee or limb bone region due to osteoarthritis and other bone-related diseases. During surgery, a new bone implant made of metal-on-metal (titanium, cobalt-chromium) or polymer-on-metal (polyethylene on titanium) is used. A significant drawback of these implants is the accumulation of metal or polymer debris, leading to inflammation and infections. Infections or inflammation caused by bacterial adherence to the implant surface result in biofilm formation at the implantation site. Additionally, infections can arise from metal debris generated by the friction and movement of the knee joint, known as implant-associated infections. This research aims to develop a bio-ceramic-based composite coating for metal implants. The composite comprises beta-tricalcium phosphate, pectin, gelatine, and polyvinylpyrrolidone (PVP) applied to a 12mm cortical titanium screw. This coating is designed to enhance the biocompatibility, antibacterial properties, and anti-inflammatory activities of the bone screw, promoting cell growth around the implant and creating a viable environment at the implantation site. Primary characterization of the composite coating materials was conducted using Scanning Electron Microscopy (SEM) with Energy Dispersive X-ray (EDX) analysis and Fourier Infrared Spectroscopy (FTIR). In-vitro antibacterial testing, anti-inflammatory testing, and degradation studies were performed to determine the stability of the coating. The results of these tests indicate that our novel composite coating materials exhibit enhanced antibacterial effects and biocompatibility. However, further research, including in-vivo and animal model testing, is necessary to confirm the suitability of the synthesized bio-ceramic-based composite coating for bone tissue engineering or bone defect repair.

    Keywords: Bone implants, dip coating, Cortical screw, Tissue Engineering, Antibac terial property

    Received: 21 Oct 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Balasubramani, J and Pradeep. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Geetha Balasubramani, Department of Electronics, Information and Bioengineering, Polytechnic University of Milan, Milan, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.