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REVIEW article
Front. Mater.
Sec. Biomaterials and Bio-Inspired Materials
Volume 11 - 2024 |
doi: 10.3389/fmats.2024.1446035
Advances of Natural Hydrogel-based Vascularization Strategies for Soft Tissue Repair
Provisionally accepted- 1 School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, Jiangsu Province, China
- 2 Zhejiang Provincial People's Hospital, Hangzhou, China
Regeneration of soft tissues, especially those requiring complex vascularization, is a major challenge in the field of tissue engineering. The current types of tissue engineering scaffolds include sponges, electric spinning silk, hydrogels, and 3D printed biomaterials. Among them, hydrogels have the unique property of mimicking extracellular matrix (ECM), which can provide a relatively stable microenvironment for cellular activities and facilitate cell adhesion, proliferation, and differentiation; thus, have become a promising scaffold. In this paper, we present a review of the commonly used types of natural hydrogels and their applications as scaffolds in tissue vascularization. First, we enumerate the importance and advantages of several types of commonly used hydrogels of natural origin in terms of fabricating vascularized tissues or organs. Second, we discuss two different formation modalities of blood vessels, as well as natural hydrogel-based vascularization strategies, including carrying growth factors, stem cell delivery, special scaffold structures and pharmaceuticalenhanced strategy. In addition, we describe the crosslinking strategies of hydrogels as scaffolds for regeneration of vascularized soft tissues, as well as the factors affecting it. Finally, new insights are provided for the development of natural hydrogel-based vascularized soft tissue regeneration research.
Keywords: natural materials1, hydrogel2, vascularization3, soft tissue4, medical applications5
Received: 08 Jun 2024; Accepted: 01 Oct 2024.
Copyright: © 2024 Xia, Guo, Wu, Yang and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fan Yang, Zhejiang Provincial People's Hospital, Hangzhou, China
Yude Ding, Zhejiang Provincial People's Hospital, Hangzhou, China
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