AUTHOR=Xie Xiaobin , Feng Xiaoxiao , Hong Lihui , Yu Xinke , Li Hongye , Zhang Hao , Liu Mingming , Wang Yimeng 

TITLE=Evaluation of antibacterial and osteogenic properties of a novel Poly (acrylic acid)-calcium-zinc biomineralized hydrogel

JOURNAL=Frontiers in Materials

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/materials/articles/10.3389/fmats.2024.1444750

DOI=10.3389/fmats.2024.1444750

ISSN=2296-8016

ABSTRACT=<p>Infectious bone defects are one of the thorny problems faced by orthopedists. Developing prosthetic materials with antimicrobial osteogenic features is a key solution. Biodegradable Polyacrylic acid (PAA)-based hydrogels have gained attention for their exceptional qualities. However, the influence of zinc ions on PAA-based mineralized hydrogels remains understudied. In this paper, Poly (acrylic acid)-calcium-zinc (PA-CZ) biomineralized hydrogel was prepared through ionic cross-linking and biomineralization. <italic>In vitro</italic> bacterial and cell tests demonstrated the hydrogel’s exceptional biocompatibility, antibacterial, and osteogenic traits, along with good mechanical strength. The PA-CZ mineralized hydrogel lays the foundation for developing orthopedic implants with antimicrobial osteogenic features and offers a promising approach for treating infected bone defects.</p>