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ORIGINAL RESEARCH article

Front. Mater.
Sec. Biomaterials and Bio-Inspired Materials
Volume 11 - 2024 | doi: 10.3389/fmats.2024.1438610

Glucosamine mitigates ischemia-reperfusion-induced acute kidney injury through antiinflammatory mechanisms

Provisionally accepted
Shengxi Jin Shengxi Jin 1Xinying Fan Xinying Fan 2Guangmin Zhang Guangmin Zhang 3Jiane Liu Jiane Liu 1Shulan Yin Shulan Yin 3Yanjing Cao Yanjing Cao 3Xiaolei Dong Xiaolei Dong 3Zheng Wang Zheng Wang 1*Xiaohua Tan Xiaohua Tan 3Shu Yan Shu Yan 1
  • 1 The Affiliated Hospital of Qingdao University, Qingdao, China
  • 2 Yantai Yuhuangding Hospital, Yantai, China
  • 3 Qingdao University, Qingdao, China

The final, formatted version of the article will be published soon.

    Acute kidney injury (AKI) is a globally prevalent clinical syndrome characterized by high morbidity and mortality. Renal ischemia-reperfusion (I/R) injury is a major contributor to AKI, commonly encountered in surgical settings. Despite extensive research, developing effective therapeutic strategies for AKI has been challenging. Similarly, finding treatments for the resulting renal interstitial fibrosis has also proven elusive. Here, we report the profound efficacy of glucosamine (GS), an endogenous amino sugar, in mitigating I/R-induced AKI.Our comprehensive analyses reveal that GS treatment significantly reduces oxidative stress, preserves mitochondrial integrity, and attenuates endoplasmic reticulum stress.Mechanistically, GS suppresses the inflammatory response in proximal convoluted tubular epithelial cells activated by TPHP. These findings offer novel insights into renal protection mechanisms and suggest GS as a promising therapeutic candidate for AKI management.

    Keywords: Acute Kidney Injury, Ischemia-reperfusion, Glucosamine, Tubular epithelial cells, Inflammatory Response

    Received: 26 May 2024; Accepted: 04 Nov 2024.

    Copyright: © 2024 Jin, Fan, Zhang, Liu, Yin, Cao, Dong, Wang, Tan and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zheng Wang, The Affiliated Hospital of Qingdao University, Qingdao, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.