AUTHOR=Lin Hao , Gao Zhe , Han Lu-Yang , Chu Jian-Jun , Xu Yang , Shen Dian-Hong 

TITLE=Antibacterial bone cement modified by long-chain nitrofuran methacrylate using liquid-phase modification strategy

JOURNAL=Frontiers in Materials

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/materials/articles/10.3389/fmats.2024.1432482

DOI=10.3389/fmats.2024.1432482

ISSN=2296-8016

ABSTRACT=<p>A novel acrylic monomer containing a nitrofuran motif, referred to as long-chain nitrofuran methacrylate (LNFMA), is reported. In comparison to the previously reported nitrofuran methacrylate (NFMA), LNFMA has a longer side chain, and when incorporated into bone cement, the resulting LNFMA bone cement exhibits improved mechanical strength. At the same concentration, NFMA-5% cement has only 21.6 ± 1.3 MPa, while LNFMA-5% cement has a compressive strength of 42.64 ± 0.94 MPa. LNFMA bone cements exhibit antimicrobial activity against <italic>Staphylococcus aureus</italic>, with LNFMA-30% cement reaching 57.38% ± 5.53%. Moreover, LNFMA cement demonstrates excellent biocompatibility both <italic>in vitro</italic> and <italic>in vivo</italic>. The results showed that LNFMA monomer had optimized mechanical strength compared with previously reported NFMA monomers, and LNFMA bone cement had good antibacterial activity and biocompatibility.</p>