AUTHOR=Fu Dapeng , Liu Junle , Ren Qilong , Ding Jinhui , Ding Heyi , Chen Xuan , Ge Xiaohu 

TITLE=Magnetic Iron Sulfide Nanoparticles as Thrombolytic Agents for Magnetocaloric Therapy and Photothermal Therapy of Thrombosis

JOURNAL=Frontiers in Materials

VOLUME=6

YEAR=2019

URL=https://www.frontiersin.org/journals/materials/articles/10.3389/fmats.2019.00316

DOI=10.3389/fmats.2019.00316

ISSN=2296-8016

ABSTRACT=<p>Non-invasive removal of thrombosis is a difficult problem in clinical vascular disease. Herein, we reported magnetic hyperthermia combined photothermal therapy for celiac vein thrombosis using Fe<sub>3</sub>S<sub>4</sub> nanoparticles as thrombolytic agents under the stimulation of a near infrared (NIR) laser and an external alternating magnetic field (AMF). Fe<sub>3</sub>S<sub>4</sub> nanoparticles showed excellent magnetothermal conversion performance under the continuous stimulation of an AMF and very good photothermal conversion performance under the irradiation of a NIR laser. Moreover, Fe<sub>3</sub>S<sub>4</sub> nanoparticles exhibited a synergistic thermal conversion effect under the co-stimulation of NIR and AMF. In addition, the Fe<sub>3</sub>S<sub>4</sub> nanoparticles possess the ability for magnetic resonance (MR) imaging with the transverse relaxivity (<italic>r</italic><sub>2</sub>) is up to 53.1 mM<sup>−1</sup> s<sup>−1</sup>. Finally, we, for the first time, proved the Fe<sub>3</sub>S<sub>4</sub> nanoparticles as a promising thrombolytic agent for both photothermal thrombolytic capacity and magnetothermal thrombolytic ability. Our work provides the insight of hyperthermia for removal of the thrombosis.</p>