AUTHOR=Mclaughlin Sarah , Podrebarac James , Ruel Marc , Suuronen Erik J. , McNeill Brian , Alarcon Emilio I. TITLE=Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far? JOURNAL=Frontiers in Materials VOLUME=3 YEAR=2016 URL=https://www.frontiersin.org/journals/materials/articles/10.3389/fmats.2016.00027 DOI=10.3389/fmats.2016.00027 ISSN=2296-8016 ABSTRACT=

Nanomaterials have attracted the interest of tissue engineers for the last two decades. Their unique properties make them promising for de novo fabrication of bio-inspired hybrid/composite materials with improved regenerative properties, including, for example, the capacity for electric conductivity and the provision of antimicrobial properties. However, to this day, the use of such materials in medical applications is rather limited and most of the studies have only reached the archetypical proof-of-concept stage. Herein, we present a review on the use of nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and nervous system. The advantages and limitations of nano-engineering materials are presented in this review alongside with the future challenges and milestones nanotechnology must overcome to make an impact in biomedical applications.