AUTHOR=Ballester-Beltrán José , Biggs Manus J. P. , Dalby Matthew J. , Salmerón-Sánchez Manuel , Leal-Egaña Aldo 

TITLE=Sensing the Difference: The Influence of Anisotropic Cues on Cell Behavior

JOURNAL=Frontiers in Materials

VOLUME=2

YEAR=2015

URL=https://www.frontiersin.org/journals/materials/articles/10.3389/fmats.2015.00039

DOI=10.3389/fmats.2015.00039

ISSN=2296-8016

ABSTRACT=<p>From tissue morphogenesis to homeostasis, cells continuously experience and respond to physical, chemical, and biological cues commonly presented in gradients. In this article, we focus our discussion on the importance of nano/micro topographic cues on cell activity, and the role of anisotropic milieus play on cell behavior, mostly adhesion and migration. We present the need to study physiological gradients <italic>in vitro</italic>. To do this, we review different cell migration mechanisms and how adherent cells react to the presence of complex tissue-like environments and cell-surface stimulation in 2D and 3D (e.g., ventral/dorsal anisotropy).</p>