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BRIEF RESEARCH REPORT article
Front. Mar. Sci.
Sec. Marine Biotechnology and Bioproducts
Volume 12 - 2025 |
doi: 10.3389/fmars.2025.1531239
Phosphomolybdic acid boosts polyunsaturated fatty acid and neutral lipid production in Phaeodactylum tricornutum
Provisionally accepted- 1 Guangdong University of Technology, Guangzhou, China
- 2 South China Botanical Garden, Chinese Academy of Sciences (CAS), Guangzhou, Guangdong Province, China
Phaeodactylum tricornutum is considered a potential lipid production platform due to its high growth rates and elevated natural neutral lipid and polyunsaturated fatty acid (PUFA) contents. Furthermore, microalgae are emerging as promising sources of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). In this study, phosphomolybdic acid (PMo12), as a photocatalyst, can enhance the synthesis of neutral lipids and PUFAs by influencing the expression of lipid metabolism-related genes and photosynthesis in P. tricornutum. We also observed the contents of EPA and PUFA in engineered microalgae nearly doubled compared to the wild type, while neutral lipid content showed a significant increase of 69.7% in engineered microalgae. Notably, the growth rate of engineered microalgae remained comparable to that of the wild type. This work presents an effective approach to enhance the production of microalgal bioproducts, suggesting that photocatalysts such as PMo12 could serve as viable alternatives to genetic engineering technology, facilitating the commercialization of microalgal biodiesel.
Keywords: Phosphomolybdic acid, Microalgae, Lipid, polyunsaturated fatty acid, EPA, DHA
Received: 20 Nov 2024; Accepted: 06 Jan 2025.
Copyright: © 2025 Peng, Xiong, Cheng, Zhong and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lin Yu, Guangdong University of Technology, Guangzhou, China
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