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REVIEW article

Front. Mar. Sci.
Sec. Marine Biotechnology and Bioproducts
Volume 11 - 2024 | doi: 10.3389/fmars.2024.1538136
This article is part of the Research Topic Harnessing Marine Natural Products for Innovative Drug Discovery and Global Health Solutions View all articles

Marine Fungi as a Goldmine for Novel Antibiotics: A 2024 Perspective

Provisionally accepted
Chengqian Pan Chengqian Pan 1*Syed Shams ul Hassan Syed Shams ul Hassan 2Muhammad Ishaq Muhammad Ishaq 3Huizi Jin Huizi Jin 2*
  • 1 School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu Province, China
  • 2 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, Shanghai Municipality, China
  • 3 Guangdong Provincial Key Laboratory for Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, China

The final, formatted version of the article will be published soon.

    The microbial diversity in oceans is considerable, widely distributed in seawater, marine sediments, and marine organisms. Compared with terrestrial resources in traditional natural product research, the living environments of marine microorganisms are starkly different. The drastic differences in survival conditions, such as high salinity, oligotrophic conditions, lack of light, and limited oxygen, determine that microorganisms exhibit distinctive characteristics in metabolism, survival modes, and adaptive mechanisms. These factors contribute to significant distinctions in secondary metabolic pathways and enzymatic reaction mechanisms between marine and terrestrial microorganisms. In this review, we summarized a total of 72 novel natural products with antibacterial activity, published in 2024, which are derived from marine-derived fungi. These products (polyketides, alkaloids, terpenoids, and peptides) are emphasized in terms of their structures and biological activities.

    Keywords: marine fungi, Antibacterial activity, Novel Natural Products, alkaloid, polyketide

    Received: 02 Dec 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Pan, Hassan, Ishaq and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Chengqian Pan, School of Pharmacy, Jiangsu University, Zhenjiang, 212013, Jiangsu Province, China
    Huizi Jin, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.