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MINI REVIEW article

Front. Mar. Sci.
Sec. Marine Biotechnology and Bioproducts
Volume 11 - 2024 | doi: 10.3389/fmars.2024.1438955
This article is part of the Research Topic Terrestrial and Marine Natural Products and Their Synthetic Scaffolds for Chronic Diseases: A Ray of Hope - Volume II View all 3 articles

Mini-Review Anti-diabetic Effects of Marine Natural Products Through Redox Modulation via Nrf2/HO-1 Cytoprotective Pathways

Provisionally accepted
Muhammad F. Nisar Muhammad F. Nisar 1,2*Mingxi Li Mingxi Li 2Jialin Xu Jialin Xu 3Chunpeng (Craig) Wan Chunpeng (Craig) Wan 2*
  • 1 Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
  • 2 School of Agricultural Sciences, Jiangxi Agricultural University, Nanchag, China
  • 3 Institute of Biochemistry and Molecular Biology, School of Life and Health Sciences, Northeastern University, Shenyang, China

The final, formatted version of the article will be published soon.

    Diabetes mellitus (DM), a major global health concern is a chronic metabolic disorder. Bioactive compounds sourced from numerous marine natural products recently have drawn attention as novel therapeutic approaches. Considering these chemicals and their role in cellular redox modulation by involving nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway, current study attempts to highlight their anti-diabetic effects and molecular mechanisms involved. Reactive oxygen species (ROS) mediated oxidative stress, inflammation, and cellular damage are linked to most of human pathologies specifically DM.Nrf2/HO-1 pathway is a key defensive mechanisms developed by the cells to combat ROS burst. Marine natural compounds have strong pharmacological potential in triggering cellular antioxidant defense mechanisms by declining oxidative damage and inflammations linked with DM. Special focus on how marine natural products potentially alleviate DM specifically type 2 diabetes (T2D) and its related issues. The literature was thoroughly analyzed to open a discussion about specific marine compounds and their well-established anti-diabetic effects to elucidate possible therapeutic applications. Furthermore, opportunities, pros and cons of us-ing these marine bioactive compounds as complementary treatment for DM also discussed.The diverse characteristics of marine natural products, specifically with regard to redox control, offer promising opportunities for drug discovery and therapeutic interventions in clinical trials.

    Keywords: Diabetes Mellitus, Therapeutics, ROS, Marine bioactive compounds, Nrf2, HO-1

    Received: 27 May 2024; Accepted: 15 Oct 2024.

    Copyright: © 2024 Nisar, Li, Xu and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Muhammad F. Nisar, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
    Chunpeng (Craig) Wan, School of Agricultural Sciences, Jiangxi Agricultural University, Nanchag, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.