AUTHOR=Jin Ye , Yu Qixuan , Li Shuangyang , Chen Tianli , Liu Da TITLE=Application of seaweed polysaccharide in bone tissue regeneration JOURNAL=Frontiers in Marine Science VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/marine-science/articles/10.3389/fmars.2023.1202422 DOI=10.3389/fmars.2023.1202422 ISSN=2296-7745 ABSTRACT=

Regeneration is a complex process influenced by many independent or combined factors, including inflammation, proliferation, and tissue remodeling. The ocean, the most extensive resource on Earth, is rich in Seaweed. With increasing research in recent years, researchers have discovered that seaweed polysaccharides have various pharmacological effects, including a particular efficacy in promoting bone tissue regeneration. However, the application of this material in the field of bone tissue engineering is very limited. However, there are few studies on the polysaccharide at home and abroad, and little is known about its potential application value in bone repair. In addition, the bioavailability of the seaweed polysaccharide is also low, and there are still many problems to be solved. For example, the ease of solubility of fucoidan in water is a key issue that restricts its practical application. In this review, we summarize the applications and mechanisms of seaweed polysaccharides in bone healing. We also propose to combine seaweed polysaccharides with novel technologies through different types of preparations, hydrogels, scaffolds, and 3D printing to improve their use in tissue healing and regeneration.