AUTHOR=Pech-Puch Dawrin , Berastegui-Cabrera Judith , Pérez-Povedano Mar , Villegas-Hernández Harold , Guillén-Hernández Sergio , Cautain Bastien , Reyes Fernando , Pachón Jerónimo , Gómez Patricia , Rodríguez Jaime , Jiménez Carlos , Sánchez-Céspedes Javier 

TITLE=Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico

JOURNAL=Frontiers in Marine Science

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/marine-science/articles/10.3389/fmars.2020.00607

DOI=10.3389/fmars.2020.00607

ISSN=2296-7745

ABSTRACT=<p>Viral infections are one of the main human health problems in recent decades and the cancer remains one of the most lethal diseases worldwide. The development of new antiviral drugs for the treatment of human adenovirus (HAdV) infections continues to be a challenging goal for medicinal chemistry. There is no specific antiviral drug approved to treat infections caused by HAdV so far and the off-label treatments currently available show great variability in their effectiveness. In relation to cancer, most of the available drugs are designed to act on specific targets by altering the activity of involved transporters and genes. Taking into account the high antiviral and antiproliferative activity against tumor cell lines displayed by some marine natural products reported in the literature, sixty five marine organisms were selected: 51 sponges (Porifera), 13 ascidians (Chordata), and 1 gorgonian (Cnidaria), collected from Yucatan Peninsula, Mexico, to evaluate their antiviral activity against human adenovirus type 5 (HAdV5) and their anticancer properties against five human tumor cell lines, namely human lung carcinoma (A549), human skin melanoma (A2058), hepatocyte carcinoma (HepG2), breast adenocarcinoma (MCF7), and pancreas carcinoma (MiaPaca-2). Eleven extracts displayed anti-HAdV activity being the organic extracts of <italic>Dysidea</italic> sp., <italic>Agelas citrina</italic>, <italic>Chondrilla</italic> sp., <italic>Spongia tubulifera</italic>, and <italic>Monanchora arbuscula</italic> the five most active ones. On the other hand, 24 extracts showed antiproliferative activity against at least one tumor cell line, being the extracts of the ascidian <italic>Eudistoma amanitum</italic> and the sponge <italic>Haliclona</italic> (<italic>Rhizoniera</italic>) <italic>curacaoensis</italic> the most active ones. This work constitutes the first wide antiviral and antiproliferative screening report of extracts from the marine sponges, ascidians, and a gorgonian collected from the Yucatan Peninsula, Mexico.</p>