AUTHOR=Huang Rui-Huan , Lin Wei , Zhang Peng , Liu Jian-Yang , Wang Dan , Li Yi-Qiang , Wang Xiao-Qiang , Zhang Cheng-Sheng , Li Wei , Zhao Dong-Lin 

TITLE=Anti-phytopathogenic Bacterial Metabolites From the Seaweed-Derived Fungus Aspergillus sp. D40

JOURNAL=Frontiers in Marine Science

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/marine-science/articles/10.3389/fmars.2020.00313

DOI=10.3389/fmars.2020.00313

ISSN=2296-7745

ABSTRACT=<p>In order to search for new lead compounds with anti-phytopathogenic bacterial activity, three pairs of new furanone derivatives, sclerotiorumins D–F (<bold>1</bold>–<bold>3</bold>), and eight known compounds (<bold>4</bold>–<bold>11</bold>) were isolated from the seaweed-derived fungus, <italic>Aspergillus</italic> sp. D40, fermented with potato dextrose seawater (PDW) medium. Their structures were determined using comprehensive spectroscopic analyzes including HRESIMS, 1D and 2D NMR data. Compounds <bold>1</bold>–<bold>4</bold> and <bold>9</bold> existed as inseparable mixtures of a pair of epimers. Penicillic acid (<bold>7</bold>) exhibited clear antibacterial activity against <italic>Ralstonia solanacearum</italic> and several other plant pathogenic bacteria with IC<sub>50</sub> values ranging from 11.6 to 58.2 <italic>μ</italic>g/mL.</p>