AUTHOR=Gogineni Vedanjali , Oh Joonseok , Waters Amanda L. , Kelly Michelle , Stone Robert , Hamann Mark T. 

TITLE=Monanchocidin A From Subarctic Sponges of the Genus Monanchora and Their Promising Selectivity Against Melanoma in vitro

JOURNAL=Frontiers in Marine Science

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/marine-science/articles/10.3389/fmars.2020.00058

DOI=10.3389/fmars.2020.00058

ISSN=2296-7745

ABSTRACT=<p>Marine sources have long been known for their potential to produce unique skeletons and various biological activities. Fractionation of the ethanol extracts of an undescribed species of <italic>Monanchora</italic><xref ref-type="bibr" rid="B4">Carter, 1883</xref> and a specimen closely comparable to <italic>Monanchora pulchra</italic> (<xref ref-type="bibr" rid="B14">Lambe, 1894/1895</xref>) (Class Demospongiae, Order Poecilosclerida, Family Crambeidae), yielded a known compound, monanchocidin A. Monanchocidin A, a secondary metabolite, showed very modest antibacterial, antifungal, and antiprotozoal activities with IC<sub>50</sub> values ranging between 255.75 and 7288.92 μM. Monanchocidin A also exhibited potent selective activity for the melanoma panel in the NCI cancer cell screening panel.</p>