AUTHOR=Menshova Roza V. , Shevchenko Natalia M. , Imbs Tatiana I. , Zvyagintseva Tatiana N. , Malyarenko Olesya S. , Zaporoshets Tatyana S. , Besednova Natalia N. , Ermakova Svetlana P. 

TITLE=Fucoidans from Brown Alga Fucus evanescens: Structure and Biological Activity

JOURNAL=Frontiers in Marine Science

VOLUME=3

YEAR=2016

URL=https://www.frontiersin.org/journals/marine-science/articles/10.3389/fmars.2016.00129

DOI=10.3389/fmars.2016.00129

ISSN=2296-7745

ABSTRACT=<p>Brown alga <italic>Fucus evanescens</italic>, widespread in the Far Eastern seas of Russia, is valuable source of sulfated polysaccharides—fucoidans with beneficial biological activities. The most homogenous fraction of fucoidan from <italic>F. evanescens</italic> was shown to be molecule containing linear main chain of alternating 2-sulfated 1,3- and 1,4-linked α-L-fucose residues. Few sulfate groups were found in position 4 of some 1,3-linked fucose residues. Acetyl groups occupied free C-3 of 1,4-linked residues and/or the C-4 of 1,3-linked fucose residues. Enzymatic hydrolysis, mild acid hydrolysis, and autohydrolysis of native fucoidan were used for elucidation of the fine structural characteristics of fucoidan from <italic>F. evanescens</italic>. The aim of this review to summarize published data on biological activities of fucoidan from <italic>F. evanescens</italic>: antiviral, anticoagulant, thrombolytic, hepatoprotective, immunomodulatory, anticancer, and their practical application.</p>