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REVIEW article

Front. Malar.
Sec. Case Management
Volume 3 - 2025 | doi: 10.3389/fmala.2025.1336324

Malaria "chemoprevention and vaccination strategies" for children living in endemic areas of Africa: A review

Provisionally accepted
Winnie Nambatya Winnie Nambatya 1*Jane Achan Jane Achan 2Moses Ocan Moses Ocan 1Bjarne Robberstad Bjarne Robberstad 3Richard Idro Richard Idro 1*
  • 1 Makerere University, Kampala, Uganda
  • 2 Malaria Consortium, Kampala, Uganda
  • 3 University of Bergen, Bergen, Hordaland, Norway

The final, formatted version of the article will be published soon.

    There has been significant progress in malaria prevention over the past 20 years, but the impact of current interventions may have peaked and in moderate to high malaria transmission areas, the earlier gains either have since stalled or reversed. Newer and more innovative strategies are urgently needed. These may include different chemoprevention strategies, vaccines, monoclonal antibodies, and injectable forms of long-acting antimalarial drugs used in combination with other interventions. In this paper, we describe the different chemoprevention strategies; their efficacy, cost-effectiveness, uptake, potential impact, and contextual factors that may impact implementation. We also assess their effectiveness in reducing the malaria burden and emerging concerns with uptake, drug resistance, stock-outs, funding, and equity and suggestions to improve application.

    Keywords: Chemoprevention, antimalarial, Malaria, Children, Morbidity, Mortality

    Received: 10 Nov 2023; Accepted: 03 Feb 2025.

    Copyright: © 2025 Nambatya, Achan, Ocan, Robberstad and Idro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Winnie Nambatya, Makerere University, Kampala, Uganda
    Richard Idro, Makerere University, Kampala, Uganda

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.