AUTHOR=Ma Xiaoyu , Wang Juejin 

TITLE=Formononetin: A Pathway to Protect Neurons

JOURNAL=Frontiers in Integrative Neuroscience

VOLUME=16

YEAR=2022

URL=https://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2022.908378

DOI=10.3389/fnint.2022.908378

ISSN=1662-5145

ABSTRACT=<p>Formononetin (FMN) is a phytoestrogen member of the flavonoid family, which has the pharmacological effects of antioxidative, antihypertensive, antitumor, and anti-infective. FMN demonstrates potential in the prevention and treatment of diseases, specifically neurological diseases, such as traumatic brain injury (TBI), spinal cord injury (SCI), ischemic stroke, cerebral ischemia-reperfusion, Alzheimer’s disease, and nerve tumor. Herein, a literature search is conducted to provide information on the signaling pathways of neuroprotection of formononetin based on the neuroprotective study. The significant neuroprotective function of FMN makes it a novel candidate for the development of drugs targeting the central nervous system.</p>