AUTHOR=Frosch Isabelle R. , Mittal Vijay A. , D’Mello Anila M. 

TITLE=Cerebellar Contributions to Social Cognition in ASD: A Predictive Processing Framework

JOURNAL=Frontiers in Integrative Neuroscience

VOLUME=16

YEAR=2022

URL=https://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2022.810425

DOI=10.3389/fnint.2022.810425

ISSN=1662-5145

ABSTRACT=<p>Functional, structural, and cytoarchitectural differences in the cerebellum are consistently reported in Autism Spectrum Disorders (ASD). Despite this, the mechanisms governing cerebellar contributions to ASD, particularly within the sociocognitive domain, are not well understood. Recently, it has been suggested that several core features of ASD may be associated with challenges creating and using prior expectations or predictions to rapidly adapt to changing stimuli or situations, also known as adaptive prediction. Importantly, neuroimaging, clinical, and animal work find that the cerebellum supports adaptive prediction in both motor and non-motor domains. Perturbations to the cerebellum <italic>via</italic> injury or neuromodulation have been associated with impairments in predictive skills. Here, we review evidence for a cerebellar role in social cognition and adaptive prediction across individuals with and without ASD.</p>