AUTHOR=Reinhard Jacqueline , Roll Lars , Faissner Andreas TITLE=Tenascins in Retinal and Optic Nerve Neurodegeneration JOURNAL=Frontiers in Integrative Neuroscience VOLUME=11 YEAR=2017 URL=https://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2017.00030 DOI=10.3389/fnint.2017.00030 ISSN=1662-5145 ABSTRACT=

Tenascins represent key constituents of the extracellular matrix (ECM) with major impact on central nervous system (CNS) development. In this regard, several studies indicate that they play a crucial role in axonal growth and guidance, synaptogenesis and boundary formation. These functions are not only important during development, but also for regeneration under several pathological conditions. Additionally, tenascin-C (Tnc) represents a key modulator of the immune system and inflammatory processes. In the present review article, we focus on the function of Tnc and tenascin-R (Tnr) in the diseased CNS, specifically after retinal and optic nerve damage and degeneration. We summarize the current view on both tenascins in diseases such as glaucoma, retinal ischemia, age-related macular degeneration (AMD) or diabetic retinopathy. In this context, we discuss their expression profile, possible functional relevance, remodeling of the interacting matrisome and tenascin receptors, especially under pathological conditions.