AUTHOR=Fuchs Perry N. , Peng Yuan Bo , Boyette-Davis Jessica A. , Uhelski Megan L. 

TITLE=The anterior cingulate cortex and pain processing

JOURNAL=Frontiers in Integrative Neuroscience

VOLUME=8

YEAR=2014

URL=https://www.frontiersin.org/journals/integrative-neuroscience/articles/10.3389/fnint.2014.00035

DOI=10.3389/fnint.2014.00035

ISSN=1662-5145

ABSTRACT=<p>The neural network that contributes to the suffering which accompanies persistent pain states involves a number of brain regions. Of primary interest is the contribution of the cingulate cortex in processing the affective component of pain. The purpose of this review is to summarize recent data obtained using novel behavioral paradigms in animals based on measuring escape and/or avoidance of a noxious stimulus. These paradigms have successfully been used to study the nature of the neuroanatomical and neurochemical contributions of the anterior cingulate cortex (ACC) to higher order pain processing in rodents.</p>