Frontiers in Immunology

Original Research

Accepted on 03 Mar 2025

HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection

in Parasite Immunology

Lucy G. Fry
CHARITY L WASHAM
Hayden Roys
Anne K. Bell
Gopinath Venugopal
Jordan T Bird
Stephanie D. Byrum
Tiffany S Weinkopff

Frontiers in Immunology

doi 10.3389/fimmu.2025.1487311

Original Research

Published on 03 Mar 2025

Exploring radiation resistance-related genes in pancreatic cancer and their impact on patient prognosis and treatment

in Cancer Immunity and Immunotherapy

Dong Dai
Sen Wang
Jiaze Li
Yu Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1524798

238 views

Original Research

Published on 03 Mar 2025

Enhancing AAV-microdystrophin gene therapy after repeat dosing by blocking phagocytosis

in Vaccines and Molecular Therapeutics

Rita Spathis
Deeva Robles Kuriplach
Sabrina Narvesen
Matthew Eybs
Karen Huang
Steven Torres
Madison King
Elizabeth Bagley
Pia Elustondo
Michael W. Lawlor

Frontiers in Immunology

doi 10.3389/fimmu.2025.1527840

642 views

Original Research

Published on 03 Mar 2025

A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus

in T Cell Biology

Beatriz Moleirinho
Margarida Paulo-Pedro
Nicole C. Martins
Emily Jelagat
Eller Conti
Tiago R. Velho
Miguel Abecasis
Rui Anjos
Afonso R. M. Almeida
Ana E. Sousa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1553535

504 views

Review

Published on 03 Mar 2025

Post-stroke depression: exploring gut microbiota-mediated barrier dysfunction through immune regulation

in Microbial Immunology

Jia Jiang
Haihua Xie
Sihui Cao
Xuan Xu
Jingying Zhou
Qianyan Liu
Changsong Ding
Mi Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1547365

232 views

Original Research

Published on 03 Mar 2025

Interpretable machine learning model for early morbidity risk prediction in patients with sepsis-induced coagulopathy: a multi-center study

in Inflammation

Ruimin Tan
Chen Ge
Jingmei Wang
Zinan Yang
He Guo
Yating Yan
Quansheng Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1552265

377 views

Opinion

Published on 03 Mar 2025

Modulation of neutrophil-to-lymphocyte ratio and gut microbiome balance in astronauts: potential benefits of novel beta-glucans during space missions

in Nutritional Immunology

Nobunao Ikewaki
Koji Ichiyama
Rajappa Senthilkumar
Senthilkumar Preethy
Samuel J. K. Abraham

Frontiers in Immunology

doi 10.3389/fimmu.2025.1538147

683 views

Original Research

Published on 03 Mar 2025

Baicalin mitigates hyperglycemia-linked intestinal epithelial barrier impairment in part by inhibiting the formation of neutrophil extracellular traps

in Mucosal Immunity

Yiqing Cai
Qinbo Yang
Xinmiao Tang
Peiwei Wang
Jingang Cui
Xiaoye Du
Teng Zhang
Yu Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1551256

177 views

Case Report

Published on 03 Mar 2025

Anti-synthetase syndrome with anti-PL-7 antibody positive in a child: a case report and literature review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jia Liu
Nana Nie
Ranran Zhang
Dahai Wang
Yi Lin
Hong Chang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1525432

105 views

Review

Published on 03 Mar 2025

Targeting cGAS-STING: modulating the immune landscape of hepatic diseases

in Cancer Immunity and Immunotherapy

Feng Xue
Yong-Kang Liu
Xiao-Ying Chen
Shan-Shan Chen
Xiang-Rong Yu
Hua-Wen Li
Li-Gong Lu
Mu-He Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1498323

216 views

Case Report

Published on 03 Mar 2025

Treatment of pro-B acute lymphoblastic leukemia and severe plaque psoriasis with anti-CD19 CAR T cells: a case report

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Ao Zhang
Guangji Zhang
Huihui Yang
Bengfa Gong
Shouyun Li
Na Wei
Hui Xue
Hui Wei
Jianxiang Wang
Shaowei Qiu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1529745

283 views

Original Research

Published on 03 Mar 2025

Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing

in Microbial Immunology

Tzu-Hsuan Chang
Yamel Cardona Gloria
Margareta J. Hellmann
Timmy Richardo
Carsten Leo Greve
Didier Le Roy
Thierry Roger
Francesca Bork
Stefanie Bugl
Johanna Jakob

Frontiers in Immunology

doi 10.3389/fimmu.2025.1497174

254 views

Case Report

Published on 03 Mar 2025

Case Report: The immune architecture of immunotherapy-induced cutaneous sarcoidosis resembles peritumoral inflammation

in Cancer Immunity and Immunotherapy

Catherine J. Wang
Jennifer Strong
Margaret E. Gatti-Mays
Wiem Lassoued
Sam Sater
Julius Strauss
Jason M. Redman
Jeffrey Schlom
James L. Gulley
Isaac Brownell

Frontiers in Immunology

doi 10.3389/fimmu.2025.1432927

246 views

Original Research

Published on 03 Mar 2025

High Smad7 marks inflammation in patients with chronic pouchitis

in Mucosal Immunity

Claudia Maresca
Andrea Iannucci
Marco Colella
Rachele Frascatani
Federica Laudisi
Elisabetta Lolli
Irene Marafini
Francesca Zorzi
Silvia Salvatori
Ivan Monteleone

Frontiers in Immunology

doi 10.3389/fimmu.2025.1549193

211 views

Mini Review

Published on 03 Mar 2025

Reprogramming tumor-associated macrophages in gastric cancer: a pathway to enhanced immunotherapy

in Cancer Immunity and Immunotherapy

Yibo He
Qianran Hong
Shiliang Chen
Jiayi Zhou
Shengliang Qiu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1558091

194 views

Original Research

Published on 03 Mar 2025

Integration of single-nuclei and spatial transcriptomics to decipher tumor phenotype predictive of relapse-free survival in Wilms tumor

in Cancer Immunity and Immunotherapy

Ran Yang
Lulu Xie
Rui Wang
Yi Li
Yifei Lu
Baihui Liu
Shuyang Dai
Shan Zheng
Kuiran Dong
Rui Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1539897

203 views

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Articles

HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection

Exploring radiation resistance-related genes in pancreatic cancer and their impact on patient prognosis and treatment

Enhancing AAV-microdystrophin gene therapy after repeat dosing by blocking phagocytosis

A backbone-based flow cytometry approach to decipher regulatory T cell trajectories in the human thymus

Post-stroke depression: exploring gut microbiota-mediated barrier dysfunction through immune regulation

Interpretable machine learning model for early morbidity risk prediction in patients with sepsis-induced coagulopathy: a multi-center study

Modulation of neutrophil-to-lymphocyte ratio and gut microbiome balance in astronauts: potential benefits of novel beta-glucans during space missions

Baicalin mitigates hyperglycemia-linked intestinal epithelial barrier impairment in part by inhibiting the formation of neutrophil extracellular traps

Anti-synthetase syndrome with anti-PL-7 antibody positive in a child: a case report and literature review

Targeting cGAS-STING: modulating the immune landscape of hepatic diseases

Treatment of pro-B acute lymphoblastic leukemia and severe plaque psoriasis with anti-CD19 CAR T cells: a case report

Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing

Case Report: The immune architecture of immunotherapy-induced cutaneous sarcoidosis resembles peritumoral inflammation

High Smad7 marks inflammation in patients with chronic pouchitis

Reprogramming tumor-associated macrophages in gastric cancer: a pathway to enhanced immunotherapy

Integration of single-nuclei and spatial transcriptomics to decipher tumor phenotype predictive of relapse-free survival in Wilms tumor