ORIGINAL RESEARCH article
Front. Immunol.
Sec. Comparative Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1597463
Immune mechanism of n-butanol extract of Clerodendrum bungei against loach infected with Aeromonas hydrophila
Provisionally accepted
- Hunan University of Chinese Medicine, Changsha, China
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Aeromonas hydrophila (A. hydrophila) is one of the most common species. Common antibacterial drugs tend to produce drug resistance and toxic side residues for a long time, while many components from traditional Chinese medicines have antibacterial, anti-inflammatory and immunity enhancing effects. Therefore, in this study, in order to evaluate the anti-inflammatory effect, the Chinese traditional medicine Clerodendrum bungei (C. bungei) was selected to pretreat the loaches infected with A. hydrophila. The metabolic pathway in loach was studied by small RNA sequencing, and the antibacterial mechanism involved in it was analyzed. The body supplements immune cells with energy in the way of autophagy to promote their maturation, differentiation and maintain cell homeostasis, and integrates information through mTOR signaling pathway to promote antigen presentation, trigger innate immunity and stimulate specific immunity. Alternatively, bacteria may activate RIG-I-like receptor signaling pathway in other ways to initiate innate immunity.
Keywords: Clerodendrum bungei Steud, Aeromonas hydrophila, antibacterial mechanism, Immunity, Chinese medicine
Received: 21 Mar 2025; Accepted: 10 Apr 2025.
Copyright: © 2025 Li, Dong, Li, Luo, Chen and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xu-Dong Zhou, Hunan University of Chinese Medicine, Changsha, China
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