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REVIEW article
Front. Immunol.
Sec. Mucosal Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1594224
This article is part of the Research TopicNatural Constituents and Mucosal Immunity: Immune Protection and Treatment of Mucosal Barriers and Microbial Flora Using Omics Technologies and Gene SequencingView all 12 articles
Potential Applications and Mechanisms of Natural Products in Mucosal-Related Diseases
Provisionally accepted
Lin Wang1
Ruishi Xie1*Caijiao Xu1Haoming Luo1Xuefeng Hua2Jiyou Yao2
Minqiang Lu2Shuo Zhou1
Ming Zhu1Dongyang Li1*
Xiaoxue Fang1*- 1Changchun University of Chinese Medicine, Changchun, China
- 2Guangzhou First People's Hospital, Guangzhou, Guangdong Province, China
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The mucosal barrier serves as a crucial defense against external pathogens and allergens, being widely distributed across the respiratory, gastrointestinal, urogenital tracts, and oral cavity. Its disruption can lead to various diseases, including inflammatory bowel disease, asthma, urinary tract infections, and oral inflammation. Current mainstream treatments for mucosa-associated diseases primarily involve glucocorticoids and immunosuppressants, but their long-term use may cause adverse effects. Therefore, the development of safer and more effective therapeutic strategies has become a focus of research. Natural products, with their multi-target and multi-system regulatory advantages, offer a promising avenue for the treatment of mucosal diseases. This review summarizes the potential applications of natural products in diseases of mucosal barrier dysfunction through mechanisms such as immune modulation, inflammation inhibition, tight junction protein restoration, and gut microbiota regulation, with the aim of providing insights for the exploration of novel therapeutic strategies.
Keywords: Mucous barrier1, Natural products2, immune regulation3, Inflammation inhibition4, Gut microbiota modulation5
Received: 15 Mar 2025; Accepted: 09 Apr 2025.
Copyright: © 2025 Wang, Xie, Xu, Luo, Hua, Yao, Lu, Zhou, Zhu, Li and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ruishi Xie, Changchun University of Chinese Medicine, Changchun, China
Dongyang Li, Changchun University of Chinese Medicine, Changchun, China
Xiaoxue Fang, Changchun University of Chinese Medicine, Changchun, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.