ORIGINAL RESEARCH article
Front. Immunol.
Sec. Viral Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1593577
This article is part of the Research TopicVascular Injury in Systemic Diseases: Current Concepts and Future PerspectivesView all 9 articles
Correlation Between Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Serum Anti-Neutrophil Cytoplasmic Antibody Formation
Provisionally accepted
- Kaifeng Central Hospital, Kaifeng, China
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Objective: To investigate the impact of SARS-CoV-2 infection on the formation of antineutrophil cytoplasmic antibodies (ANCA).Methods: Serum samples from 154 patients infected with SARS-CoV-2 were collected and tested for ANCA and antinuclear antibodies (ANA) using indirect immunofluorescence assay (IFA). Enzyme-linked immunosorbent assay (ELISA) was used to confirm the target antigens in ANCA fluorescence-positive samples. Eightyseven healthy individuals were selected as the control group. Statistical analysis was performed using SPSS 26.0 software, with P < 0.05 considered statistically significant.The ANCA fluorescence positivity rate in the control group (1.1%) was not significantly different from that in COVID-19 positive patients (2.5%) (χ² = 0.574, P > 0.05). Among COVID-19 positive patients, 4 cases (2.5%) were ANCA fluorescence positive, while 10 cases (6.4%) were ANA positive. The difference between these two rates was not statistically significant (χ² = 2.694, P > 0.05).The Omicron variant of SARS-CoV-2 has minimal association with the formation of serum ANCA.
Keywords: anti-neutrophil cytoplasmic antibody, Antinuclear antibody, Indirect immunofluorescence assay, Infection, Severe acute respiratory syndrome coronavirus
Received: 17 Mar 2025; Accepted: 24 Apr 2025.
Copyright: © 2025 Huang, Zang, Li, Li, Ma, Zhao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hang Li, Kaifeng Central Hospital, Kaifeng, China
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