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CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1588471
This article is part of the Research TopicTherapeutic Strategies for Thrombotic MicroangiopathyView all articles
Early caplacizumab and obinutuzumab enable successful treatment of relapsing thrombotic thrombocytopenic purpura without therapeutic plasma exchange: a case report
Provisionally accepted- 1Landeskrankenhaus Feldkirch, Feldkirch, Austria
- 2Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Feldkirch, Austria
- 3Agency for Preventive and Social Medicine (aks), Bregenz, Austria
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Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening disorder due to a severe acquired or inherited ADAMTS13 deficiency. So far, therapeutic algorithms almost universally include the prompt initiation of therapeutic plasma exchange (TPE). We firstly report a 55-year-old female with a history of relapsing TTP who was managed exclusively with caplacizumab, steroids and the second generation fully humanized anti-CD20 monoclonal antibody obinutuzumab during a relapse without the need of TPE throughout the whole disease course. This case illustrates the safety and effectiveness of a TPE-free TTP management using prompt initiation of caplacizumab and obinutuzumab.
Keywords: Caplacizumab, Obinutuzumab, thrombotic microangiopathy, therapeutic plasma exchange, thrombotic thrombocytopenic purpura
Received: 05 Mar 2025; Accepted: 07 Apr 2025.
Copyright: © 2025 Schimpf, Haller and Zitt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Emanuel Zitt, Landeskrankenhaus Feldkirch, Feldkirch, Austria
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.