ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1582573
This article is part of the Research TopicHarnessing Big Data for Precision Medicine: Revolutionizing Diagnosis and Treatment StrategiesView all 40 articles
IFI27 as a Potential Biomarker and Therapeutic Target in Cervical Cancer: Implications for Anoikis Response
Provisionally accepted
- First Affiliated Hospital of Jilin University, Changchun, China
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Cervical cancer is a leading cause of morbidity and mortality among women worldwide.Anoikis, a form of programmed cell death triggered by detachment from the extracellular matrix, is crucial in cancer progression. Cancer cells often evade anoikis to enhance survival and metastasis. In this study, we examined the role of anoikisrelated genes in cervical cancer by integrating single-cell RNA sequencing with spatial transcriptomics. Using a comprehensive scoring algorithm, we identified a significant enrichment of anoikis-related genes in cervical cancer epithelial cells. Further analysis revealed distinct epithelial cell populations: tumor epithelial cells, epithelial-tomesenchymal transition (EMT) cells, and keratinized epithelial cells, with the highest enrichment in tumor epithelial cells. Notably, the IFI27 gene was significantly more expressed in tumor epithelial cells compared to normal tissue. By leveraging spatial transcriptomics, we explored the role of IFI27 in tumor epithelial cells and identified key differences between IFI27-positive and IFI27-negative populations. Additionally, analysis of large-scale transcriptomic data showed that cervical cancer patients with high infiltration of IFI27-positive tumor epithelial cells had better prognosis and improved responses to immunotherapy. This study provides new insights into the connection between anoikis and cervical cancer, highlighting potential therapeutic targets IFI27.
Keywords: cervical cancer, Single cell sequencing, Spatial transcriptome, Anoikis, IFI27
Received: 24 Feb 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Man, He, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Baogang Wang, First Affiliated Hospital of Jilin University, Changchun, China
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