CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1582265
A Case of Subacute Combined Degeneration of the Spinal Cord Associated with Chronic Atrophic Gastritis, Macrocytic Anemia, and Positive Anti-sulfatide IgM and
Provisionally accepted
- 1Department of Neurology, Huizhou First Hospital, Huizhou, China
- 2Department of Radiology, Huizhou First Hospital, Huizhou, China
- 3Department of Critical Care Medicine, Huizhou First Hospital, Huizhou, China
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Background: Anti-sulfatide antibodies are autoantibodies associated with various neurological disorders. They have been identified in several conditions, including Guillain-Barré syndrome, multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. Subacute combined degeneration of the spinal cord is mainly caused by vitamin B12 deficiency. Chronic atrophic gastritis is a complex condition characterized by the atrophy and inflammation of the gastric mucosa. To date, there have been no reported cases of patients with Subacute combined degeneration of the spinal cord co-occurring with chronic atrophic gastritis and positive anti-sulfatide antibodies. Case Presentation: A 58-year-old male patient presented with symmetrical and progressive numbness in his limbs. Although he did not experience gait instability, he had difficulty performing fine motor tasks with his upper limbs. We reviewed the patient's medical history and analyzed his blood tests, imaging studies, and gastroscopic results. The patient met the criteria for Subacute combined degeneration of the spinal cord, chronic atrophic gastritis, macrocytic anemia and anti-sulfatide antibody positivity. His symptoms improved following treatment. Conclusion: This first report on the coexistence of positive anti-sulfatide antibodies and Subacute combined degeneration of the spinal cord including chronic atrophic gastritis and macrocytic anemia will enhance our understanding of the relationships between these conditions.
Keywords: Subacute combined degeneration of the spinal cord, anti-sulfatide antibodies, Chronic atrophic gastritis, Macrocytic anemia, case
Received: 24 Feb 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Zhuang, Li, Kong, Lin and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Caiming Li, Department of Neurology, Huizhou First Hospital, Huizhou, China
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