Corrigendum: Characterization of intrahepatic B cells in acute-onchronic liver failure

Yudong Zhao¹Wei He²Chenchen Wang¹Nana Cui²Changjie Yang¹Zhengrui You²Bisheng Shi^3*Lei Xia^1*Xiaosong Chen^1*

• ¹Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
• ²National Health Council (NHC) Key Laboratory of Digestive Diseases, Renji Hospital, School of Medicine, Shanghai Institute of Digestive Disease, Shanghai Jiao Tong University, Division of Gastroenterology and Hepatology , Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Shanghai, China
• ³Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

In the published article, there was an error in Figure 1 as published. A single point below 20 in the Cirrhosis group and three points near 80 in the ACLF group were determined to be incorrect. These errors have been corrected, and the updated data points have been incorporated into the figure. Consequently, the corresponding data in Figures 1D, 1E, and 1F have also been revised. The corrected Figure 1 and its caption, “Divergent peripheral B cell subsets in ACLF, Cirrhosis and HC,” appear below. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.In the published article, there were errors in Figure 5 as published. The erroneous data was in patients with acute-on-chronic liver failure (ACLF). We preliminarily collected all the liver sections from patients receiving liver transplantation and analyzed their liver B cells. we first excluded hepatocarcinoma and then selected patients with high levels of inflammation, mainly based on their total bilirubin levels. As a result, Primary Biliary Cholangitis (PBC) patients were primarily included due to their high jaundice levels. According to the Asian Pacific Association for the Study of the Liver (APASL) diagnostic criteria, ACLF patients should meet with criteria of acute jaundice worsening, coagulopathy, and the presence of extrahepatic organ failure. The coagulation function (PT, INR) of 4 PBC patients did not meet the criteria and generally did not have extrahepatic organ failure, we excluded PBC patients from the ACLF cohort and collected another four Chronic Hepatitis B (CHB)-ACLF liver in our analysis in Figure 2. Notably, the supplementary table related to patient information in the paper is correct and the intergroup comparisons presented in Figure 2 were conducted using this updated ACLF cohort. Regrettably, the analysis of the new ACLF cohort with clinical parameters was not promptly updated in our correlation analysis in Figure 5. We have reanalyzed the data and recalculated the p-values and correlation coefficients (R values) in Figure 5. The corrected Figure 5 and its caption, “The association of intrahepatic B cells subsets with clinical parameters in ACLF patients,” appear below. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.In the published article, there were errors in TABLE 1. The demographic and clinical characteristics were incorrectly matched due to adjustments in patient inclusion and exclusion during cohort refinement. The corrected TABLE 1 and its caption, “The demographic and clinical characteristics of subjects,” appear below.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.